Targeting interleukin-4 receptor α with hybrid peptide for effective cancer therapy.

@article{Yang2012TargetingIR,
  title={Targeting interleukin-4 receptor α with hybrid peptide for effective cancer therapy.},
  author={Liying Yang and Tomohisa Horibe and Masayuki Kohno and Mari Haramoto and Koji Ohara and Raj K. Puri and Koji Kawakami},
  journal={Molecular cancer therapeutics},
  year={2012},
  volume={11 1},
  pages={235-43}
}
Interleukin-4 receptor α (IL-4Rα) chain is highly expressed on the surface of various human solid tumors. We designed a novel hybrid peptide termed IL-4Rα-lytic peptide that targets the IL-4Rα chain. The IL-4Rα-lytic peptide contains a target moiety to bind to IL-4Rα and a cellular toxic lytic peptide that selectively kills cancer cells. The anticancer activity of the IL-4Rα-lytic peptide was evaluated in vitro and in vivo. It was found that the IL-4Rα-lytic peptide has cytotoxic activity in… CONTINUE READING
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