Targeting insulin-like growth factor-1 to treat Alzheimer's disease.

  title={Targeting insulin-like growth factor-1 to treat Alzheimer's disease.},
  author={Ign{\'a}cio Torres-Aleman},
  journal={Expert opinion on therapeutic targets},
  volume={11 12},
The 'amyloid cascade hypothesis' proposes that disturbances in amyloid metabolism cause Alzheimer's disease (AD). However, a comprehensive explanation of the mechanisms leading to brain amyloidosis is still pending. Building on previous findings with insulin, and recent observations with insulin-like growth factor-1 (IGF-1) in AD pathology, new evidence suggests that the interaction of environmental factors and inheritance lead to abnormally reduced input/traffic of serum IGF-1 at the blood… CONTINUE READING


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