Targeting inhibitor of apoptosis proteins to block vascular inflammation.

Abstract

The tumor necrosis factor (TNF) receptor superfamily (TNFRSF) represents a large number of membranebound and secreted proteins that regulate inflammation and other functions in the vasculature and other tissues. Members of the TNFRSF are involved in the pathogenesis of atherosclerosis,1 and treatment with anti-TNF antibodies enhances vascular function in… (More)
DOI: 10.1161/ATVBAHA.111.235762

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