Targeting information-processing deficit in schizophrenia: a novel approach to psychotherapeutic drug discovery.

@article{Hajs2006TargetingID,
  title={Targeting information-processing deficit in schizophrenia: a novel approach to psychotherapeutic drug discovery.},
  author={Mih{\'a}ly Haj{\'o}s},
  journal={Trends in pharmacological sciences},
  year={2006},
  volume={27 7},
  pages={391-8}
}
Current observations indicate that dysfunction of neuronal circuitry dynamics contributes to the abnormal information processing in the brain in schizophrenia. It is presumed that disrupted auditory gating, abnormal P300-evoked potentials and deficits in mismatch negativity in schizophrenic patients indicate impaired processing of information. Recently, abnormalities in neuronal synchrony and oscillatory activity have been postulated as the mechanisms that underlie the distorted perception and… CONTINUE READING

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