Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD).

@article{Impellizzeri2014TargetingIN,
  title={Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD).},
  author={Daniela Impellizzeri and Emanuela Esposito and James Attley and Salvatore Cuzzocrea},
  journal={Pharmacological research},
  year={2014},
  volume={81},
  pages={91-102}
}
Chronic inflammation and oxidative stress, features that are closely associated with nuclear factor (NF-κB) activation, play a key role in the development and progression of chronic kidney disease (CKD). Several animal models and clinical trials have clearly demonstrated the effectiveness of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) therapy to improve glomerular/tubulointerstitial damage, reduce proteinuria, and decrease CKD progression, but CKD… CONTINUE READING
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