Targeting inflammasome/IL-1 pathways for cancer immunotherapy

  title={Targeting inflammasome/IL-1 pathways for cancer immunotherapy},
  author={Beichu Guo and Shunjun Fu and Jinyu Zhang and Bei Liu and Zihai Li},
  booktitle={Scientific reports},
The inflammatory microenvironment has been shown to play important roles in various stages of tumor development including initiation, growth, and metastasis. The inflammasome is a critical innate immune pathway for the production of active IL-1β, a potent inflammatory cytokine. Although inflammasomes are essential for host defense against pathogens and contribute to autoimmune diseases, their role in tumor progression remains controversial. Here, our results demonstrate that the inflammasome… CONTINUE READING
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