Targeting hypoxia tolerance in cancer.

  title={Targeting hypoxia tolerance in cancer.},
  author={Bradly G. Wouters and Twan van den Beucken and Michael G Magagnin and Philippe Lambin and Costas Koumenis},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  volume={7 1},
Regulation of tissue oxygen homeostasis is critical for cell function, proliferation and survival. Evidence for this continues to accumulate along with our understanding of the complex oxygen-sensing pathways present within cells. Several pathophysiological disorders are associated with a loss in oxygen homeostasis, including heart disease, stroke, and cancer. The microenvironment of tumors in particular is very oxygen heterogeneous, which may explain much of our difficulty in treating cancer… CONTINUE READING