Targeting human telomerase for cancer therapeutics

@article{Guittat2004TargetingHT,
  title={Targeting human telomerase for cancer therapeutics},
  author={Lionel Guittat and Patrizia Alberti and Dennis G{\'o}mez and Anne De Cian and Ga{\"e}lle Pennarun and Thibault Lemarteleur and Chafk{\'e} Ahmed Belmokhtar and Rajaa Paterski and Hamid Morjani and Chantal Trentesaux and Eliane Mandine and François Boussin and Patrick Mailliet and L. Lacroix and J F Riou and Jean-Louis Mergny},
  journal={Cytotechnology},
  year={2004},
  volume={45},
  pages={75-90}
}
The enzyme telomerase is involved in the replication of telomeres, specialized structures that cap and protect the ends of chromosomes. Its activity is required for maintenance of telomeres and for unlimited lifespan, a hallmark of cancer cells. Telomerase is overexpressed in the vast majority of human cancer cells and therefore represents an attractive target for therapy. Several approaches have been developed to inhibit this enzyme through the targeting of its RNA or catalytic components as… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 146 REFERENCES

Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cells

J. H. Kim, G. E. Lee, S. W. Kim, I. K. Chung
  • Biochem. J. 373: 523–529.
  • 2003
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Benzoindoloquinolines interact with DNA quadruplexes and inhibit telomerase

P. Alberti, P. Schmidt, +3 authors J. L. Mergny
  • Bioorg. Med. Chem. Lett. 12: 1071–1074.
  • 2002
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

A highly selective telo

K. Damm, U. Hemmann, +18 authors A. Schnapp
  • 2001
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL