Targeting human epidermal growth factor receptor 2 by a cell-penetrating peptide-affibody bioconjugate.

@article{Govindarajan2012TargetingHE,
  title={Targeting human epidermal growth factor receptor 2 by a cell-penetrating peptide-affibody bioconjugate.},
  author={Srinath Govindarajan and Jeyarajan Sivakumar and Prathyusha Garimidi and Nandini Rangaraj and Jerald Mahesh Kumar and N. Mallikarjuna Rao and Vijaya Gopal},
  journal={Biomaterials},
  year={2012},
  volume={33 8},
  pages={2570-82}
}
Cell-penetrating peptide (CPP)-based delivery systems represent a strategy that facilitates DNA import efficiently and non-specifically into cells. To introduce specificity, we devised an approach that combines a cell-penetrating peptide, TAT-Mu (TM) and a targeting ligand, an HER2 antibody mimetic-affibody (AF), designated as TMAF to deliver nucleic acids into the cells. In this study, we synthesized TMAF protein and its truncated versions, i.e. MAF and AF, by expressing the corresponding… CONTINUE READING
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