Targeting host calpain proteases decreases influenza A virus infection.

@article{Blanc2016TargetingHC,
  title={Targeting host calpain proteases decreases influenza A virus infection.},
  author={Fany Blanc and Laetitia Furio and Doroth{\'e}e Moisy and Hui-ling Yen and Michel Chignard and Emmanuel Letavernier and Nadia Naffakh and Chris Ka Pun Mok and M. Si-Tahar},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2016},
  volume={310 7},
  pages={
          L689-99
        }
}
Influenza A viruses (IAV) trigger contagious acute respiratory diseases. A better understanding of the molecular mechanisms of IAV pathogenesis and host immune responses is required for the development of more efficient treatments of severe influenza. Calpains are intracellular proteases that participate in diverse cellular responses, including inflammation. Here, we used in vitro and in vivo approaches to investigate the role of calpain signaling in IAV pathogenesis. Calpain expression and… 
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