Targeting homologous recombination and telomerase in Barrett’s adenocarcinoma: Impact on telomere maintenance, genomic instability, and tumor growth

@inproceedings{Lu2014TargetingHR,
  title={Targeting homologous recombination and telomerase in Barrett’s adenocarcinoma: Impact on telomere maintenance, genomic instability, and tumor growth},
  author={Renquan Lu and Jagannath Pal and Leutz Buon and Puru Nanjappa and Jialan Shi and Mariateresa T Fulciniti and Yu-Tzu Tai and Lin Guo and Min Yu and Sergei M. Gryaznov and Nikhil C. Munshi and Masood A. Shammas},
  booktitle={Oncogene},
  year={2014}
}
Homologous recombination (HR), a mechanism to accurately repair DNA in normal cells, is deregulated in cancer. Elevated/deregulated HR is implicated in genomic instability and telomere maintenance, which are critical lifelines of cancer cells. We have previously shown that HR activity is elevated and significantly contributes to genomic instability in Barrett’s esophageal adenocarcinoma (BAC). The purpose of this study was to evaluate therapeutic potential of HR inhibition, alone and in… CONTINUE READING