Targeting hepatocytes for drug and gene delivery: emerging novel approaches and applications.

  title={Targeting hepatocytes for drug and gene delivery: emerging novel approaches and applications.},
  author={Jian Wu and Michael H Nantz and Mark A. Zern},
  journal={Frontiers in bioscience : a journal and virtual library},
The asialoglycoprotein receptor (ASGP-R) on mammalian hepatocytes provides a unique means for the development of liver-specific carriers, such as liposomes, recombinant lipoproteins, and polymers for drug or gene delivery to the liver, especially to hepatocytes. The abundant receptors on the cells specifically recognize ligands with terminal galactose or N-acetylgalactosamine residues, and endocytose the ligands for an intracellular degradation process. The use of its natural ligand, i.e… CONTINUE READING
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