Targeting heat shock proteins in metastatic castration-resistant prostate cancer

@article{Azad2015TargetingHS,
  title={Targeting heat shock proteins in metastatic castration-resistant prostate cancer},
  author={Arun A. Azad and Amina Zoubeidi and Martin E. Gleave and Kim N. Chi},
  journal={Nature Reviews Urology},
  year={2015},
  volume={12},
  pages={26-36}
}
The survival of malignant cells is constantly threatened by a myriad of cellular insults. In the context of such proteotoxic stress, cancer cells activate cytoprotective adaptive pathways. Heat shock proteins (HSPs) are highly conserved molecular chaperones that are expressed at low levels under normal conditions, but upregulated by cellular stress. As… CONTINUE READING