Targeting growth factor receptors with fusion toxins.

  title={Targeting growth factor receptors with fusion toxins.},
  author={Robert J. Kreitman and David Fitzgerald and Ira Pastan},
  journal={International journal of immunopharmacology},
  volume={14 3},
Recombinant toxins which bind to growth factor receptors have been prepared and used to kill cells responsible for malignant or autoimmune disease. Our strategy has been to genetically fuse ligands to different forms of Pseudomonas exotoxin which due to mutations or deletions do not bind to normal cells. The resulting recombinant chimeric toxins, in concentrations often less than 1 ng/ml, selectively kill cells expressing the appropriate growth factor receptor. The ligand may be a growth factor… CONTINUE READING