Targeting growth factor and cytokine receptors with recombinant peptide libraries.

@article{Dower1998TargetingGF,
  title={Targeting growth factor and cytokine receptors with recombinant peptide libraries.},
  author={W. J. Dower},
  journal={Current opinion in chemical biology},
  year={1998},
  volume={2 3},
  pages={328-34}
}
  • W. J. Dower
  • Published 1998 in Current opinion in chemical biology
The single-transmembrane-spanning receptors of cytokines and growth factors have historically proven resistant to the small-molecule screening efforts of the pharmaceutical industry. Advances in combinatorial library approaches to ligand discovery have begun to show success with these targets. There are several recent reports of peptides, derived from randomly assembled collections of L-peptides expressed in recombinant display vectors, that are high-affinity antagonists and even agonists of… CONTINUE READING