Targeting group II PAKs in cancer and metastasis

@article{Eswaran2008TargetingGI,
  title={Targeting group II PAKs in cancer and metastasis},
  author={Jeyanthy Eswaran and Meera Soundararajan and Stefan Knapp},
  journal={Cancer and Metastasis Reviews},
  year={2008},
  volume={28},
  pages={209-217}
}
The p21 activated kinases (PAKs) play an essential role in cell signaling and control a variety of cellular functions including cell motility, survival, angiogenesis and mitosis. PAKs are important regulators in growth factor signaling, cytoskeletal reorganization and growth factor-mediated cell migration. Overexpression of PAKs has been detected in many cancers and linked to increased migration potential, anchorage independent growth and metastasis. Six isoforms of PAKs are expressed in human… CONTINUE READING
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