Targeting gp130 to prevent inflammation and promote insulin action.

  title={Targeting gp130 to prevent inflammation and promote insulin action.},
  author={Michael James Kraakman and Tamara Louise Allen and Martin Whitham and P. Iliades and Helene L Kammoun and E. Collantes Estevez and Graeme Iain Lancaster and Mark Anthony Febbraio},
  journal={Diabetes, obesity & metabolism},
  volume={15 Suppl 3},
Obesity and type 2 diabetes are now the most prevalent metabolic diseases in the Western world and the development of new strategies to treat these metabolic diseases is most warranted. Obesity results in a state of chronic low-grade inflammation in metabolically active tissues such as the liver, adipose tissue, brain and skeletal muscle. Work in our laboratory has focussed on the role of the cytokine interleukin-6 (IL)-6 and other IL-6-like cytokines that signal through the gp130 receptor… CONTINUE READING