Targeting glycosylation pathways and the cell cycle: sugar-dependent activity of butyrate-carbohydrate cancer prodrugs.

@article{Sampathkumar2006TargetingGP,
  title={Targeting glycosylation pathways and the cell cycle: sugar-dependent activity of butyrate-carbohydrate cancer prodrugs.},
  author={Srinivasa-Gopalan Sampathkumar and Mark B. Jones and Michael Adam Meledeo and Christopher T. Campbell and Sean Choi and Kaoru Hida and Prasra Gomutputra and Anthony Sheh and Tim J. Gilmartin and Steven Robert Head and Kevin J. Yarema},
  journal={Chemistry & biology},
  year={2006},
  volume={13 12},
  pages={1265-75}
}
Short-chain fatty acid (SCFA)-carbohydrate hybrid molecules that target both histone deacetylation and glycosylation pathways to achieve sugar-dependent activity against cancer cells are described in this article. Specifically, n-butyrate esters of N-acetyl-D-mannosamine (But4ManNAc, 1) induced apoptosis, whereas corresponding N-acetyl-D-glucosamine (But4GlcNAc, 2), D-mannose (But5Man, 3), or glycerol (tributryin, 4) derivatives only provided transient cell cycle arrest. Western blots, reporter… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 65 references

Characterization of the metabolic flux and apoptotic effects of O-hydroxyl- and N-acetylmannosamine (ManNAc) analogs in Jurkat (human T-lymphoma-derived) cells

E. J. Kim, Sampathkumar, +4 authors K. J. Yarema
J. Biol • 2004
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…