Targeting gene therapy vectors to CNS malignancies.


Gene therapy offers significant advantages to the field of oncology with the addition of specifically and uniquely engineered mechanisms of halting malignant proliferation through cytotoxicity or reproductive arrest. To confer a true benefit to the therapeutic ratio (the relative toxicity to tumor compared to normal tissue) a vector or the transgene it… (More)


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@article{Spear1998TargetingGT, title={Targeting gene therapy vectors to CNS malignancies.}, author={Matthew Spear and Ulrich Herrlinger and Nikolai G. Rainov and Peter A. Pechan and Ralf Weissleder and Xandra O Breakefield}, journal={Journal of neurovirology}, year={1998}, volume={4 2}, pages={133-47} }