Targeting Signal‐Transducer‐and‐Activator‐of‐Transcription‐3 for Prevention and Therapy of Cancer

@article{Aggarwal2006TargetingSF,
  title={Targeting Signal‐Transducer‐and‐Activator‐of‐Transcription‐3 for Prevention and Therapy of Cancer},
  author={B. Aggarwal and G. Sethi and K. Ahn and S. Sandur and M. Pandey and A. B. Kunnumakkara and B. Sung and H. Ichikawa},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1091}
}
Abstract:  Recent evidence indicates a convergence of molecular targets for both prevention and therapy of cancer. Signal‐transducer‐and‐activator‐of‐transcription‐3 (STAT3), a member of a family of six different transcription factors, is closely linked with tumorigenesis. Its role in cancer is indicated by numerous avenues of evidence, including the following: STAT3 is constitutively active in tumor cells; STAT3 is activated by growth factors (e.g., EGF, TGF‐α, IL‐6, hepatocyte growth factor… Expand
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