Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death

@inproceedings{Smirlis2010TargetingEP,
  title={Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death},
  author={Despina Smirlis and Michael Duszenko and Antonio Ram{\'o}n Jim{\'e}nez Ruiz and Efstathia V Scoulica and Patrick Bastien and Nicolas Fasel and Ketty P. Soteriadou},
  booktitle={Parasites & Vectors},
  year={2010}
}
Apoptosis is a normal component of the development and health of multicellular organisms. However, apoptosis is now considered a prerogative of unicellular organisms, including the trypanosomatids of the genera Trypanosoma spp. and Leishmania spp., causative agents of some of the most important neglected human diseases. Trypanosomatids show typical hallmarks of apoptosis, although they lack some of the key molecules contributing to this process in metazoans, like caspase genes, Bcl-2 family… CONTINUE READING

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