Targeting epidermal growth factor receptor-associated signaling pathways in non-small cell lung cancer cells: implication in radiation response.

@article{Choi2010TargetingEG,
  title={Targeting epidermal growth factor receptor-associated signaling pathways in non-small cell lung cancer cells: implication in radiation response.},
  author={Eun Jung Choi and Yun Kyeong Ryu and So Yeon Kim and Hong Gyun Wu and Jae Sung Kim and Il Han Kim and In Ah Kim},
  journal={Molecular cancer research : MCR},
  year={2010},
  volume={8 7},
  pages={1027-36}
}
Several studies have shown solid evidence for the potential value of targeting epidermal growth factor receptor (EGFR) signaling to enhance the antitumor activity of radiation. However, therapeutic resistance has emerged as an important clinical issue. Here, we investigated whether strategies for targeting EGFR-associated downstream signaling would radiosensitize a panel of non-small cell lung cancer cell lines. Inhibition of K-RAS using RNA interference attenuated downstream signaling and… CONTINUE READING

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