Targeting enzymes to the right compartment: metabolic engineering for itaconic acid production by Aspergillus niger.

@article{Blumhoff2013TargetingET,
  title={Targeting enzymes to the right compartment: metabolic engineering for itaconic acid production by Aspergillus niger.},
  author={Marzena L. Blumhoff and Matthias G. Steiger and Diethard Mattanovich and Michael G Sauer},
  journal={Metabolic engineering},
  year={2013},
  volume={19},
  pages={26-32}
}
Itaconic acid is an unsaturated dicarboxylic acid which has a high potential as a biochemical building block. It can be microbially produced from some Aspergillus species, such as Aspergillus itaconicus and Aspergillus terreus. However, the achieved titers are significantly lower as compared to the citric acid production by A. niger. Heterologous expression of cis-aconitate decarboxylase in A. niger leads to the accumulation of small amounts of itaconic acid. Additional expression of aconitase… CONTINUE READING
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