Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension.

@article{Tuder2012TargetingEM,
  title={Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension.},
  author={Rubin M. Tuder and Laura A Davis and Brian B Graham},
  journal={American journal of respiratory and critical care medicine},
  year={2012},
  volume={185 3},
  pages={260-6}
}
This perspective highlights advances in the understanding of the role of cellular metabolism in the pathogenesis of pulmonary hypertension. Insights gained in the past 20 years have revealed several similarities between the cellular processes underlying the pulmonary vascular remodeling in pulmonary hypertension and those seen in cancer processes. In line with these insights, there is increasing recognition that abnormal cellular metabolism, notably of aerobic glycolysis (the "Warburg effect… CONTINUE READING

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