Targeting endothelin ETA and ETB receptors inhibits antigen-induced neutrophil migration and mechanical hypernociception in mice

@article{Verri2008TargetingEE,
  title={Targeting endothelin ETA and ETB receptors inhibits antigen-induced neutrophil migration and mechanical hypernociception in mice},
  author={Waldiceu A Verri and Thiago M Cunha and Danilo A. Magro and Ana Tereza Gomes Guerrero and Silvio M Vieira and Vanessa Carregaro and Guilherme R. L. Souza and Maria das Graças Henriques and S{\'e}rgio Henrique S. Ferreira and Fernando Q Cunha},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2008},
  volume={379},
  pages={271-279}
}
Endothelin may contribute to the development of inflammatory events such as leukocyte recruitment and nociception. Herein, we investigated whether endothelin-mediated mechanical hypernociception (decreased nociceptive threshold, evaluated by electronic pressure-meter) and neutrophil migration (myeloperoxidase activity) are inter-dependent in antigen challenge-induced Th1-driven hind-paw inflammation. In antigen challenge-induced inflammation, endothelin (ET) ETA and ETB receptor antagonism… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 21 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 63 REFERENCES

Similar Papers

Loading similar papers…