Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells

@article{Ashour2013TargetingEF,
  title={Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells},
  author={Ahmed Ashour and Abdel-Aziz H. Abdel-Aziz and Ahmed M. Mansour and Sultan Neslihan Alpay and Longfei Huo and Bulent Ozpolat},
  journal={Apoptosis},
  year={2013},
  volume={19},
  pages={241-258}
}
Pancreatic cancer (PaCa) is one of the most aggressive, apoptosis-resistant and currently incurable cancers with a poor survival rate. Eukaryotic elongation factor-2 kinase (eEF-2K) is an atypical kinase, whose role in PaCa survival is not yet known. Here, we show that eEF-2K is overexpressed in PaCa cells and its down-regulation induces apoptotic cell death. Rottlerin (ROT), a polyphenolic compound initially identified as a PKC-δ inhibitor, induces apoptosis and autophagy in a variety of… 

Eukaryotic elongation factor-2 kinase (eEF2K): a potential therapeutic target in cancer

Findings have led to the conclusions that eEF2K may contribute to carcinogenesis, and thus being utilized as a potential target for future cancer therapy.