Targeting drugs to the colon: delivery systems for oral administration.

@article{Ashford1994TargetingDT,
  title={Targeting drugs to the colon: delivery systems for oral administration.},
  author={Mark Ashford and John T. Fell},
  journal={Journal of drug targeting},
  year={1994},
  volume={2 3},
  pages={241-57}
}
The oral delivery of drugs to the colon has applications in a variety of therapeutic areas. This review is concerned with the approaches taken to achieve a universal system for delivery. The design of such a system requires the identification and exploitation of a unique feature of the colonic environment. The use of transit times, pH and bacterial enzymes are critically assessed. In addition, the system must provide protection for the drug during transit to the colon. Upper gastro-intestinal… CONTINUE READING

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