Targeting diphtheria toxin to growth factor receptors.

  title={Targeting diphtheria toxin to growth factor receptors.},
  author={Jaime Murphy and J C Vanderspek},
  journal={Seminars in cancer biology},
  volume={6 5},
Biochemical, genetic and X-ray crystallographic analysis of diphtheria toxin have demonstrated that the native toxin is composed of three structural domains that function in an ordered fashion to intoxicate a eukoryotic cell. With the knowledge that, if delivered to the cytosol, a single molecule of the catalytic domain is lethal for the cell, we have used recombinant DNA methods to genetically replace the native toxin receptor binding domain with a series of growth factors. The resulting… CONTINUE READING


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