Targeting delivery and deep penetration using multistage nanoparticles for triple-negative breast cancer

@inproceedings{Ruan2015TargetingDA,
  title={Targeting delivery and deep penetration using multistage nanoparticles for triple-negative breast cancer},
  author={Shaobo Ruan and Li Zhang and Jiantao Chen and Tingwei Cao and Yuting Yang and Yayuan Liu and Qin He and Fabao Gao and Huile Gao},
  year={2015}
}
Targeting delivery and deep penetration have been attracting tremendous attention in triple-negative breast cancer (TNBC) theranostics. Herein, we reported a novel multistage system (G-AuNPs-DOX-RRGD) with an active targeting effect and size-changeable property to inhibit tumor growth and metastasis in 4T1 xenograft bearing mice. The system was constructed through fabricating small-size gold nanoparticles (AuNPs) onto matrix metalloproteinase-2 (MMP-2) degradable gelatin nanoparticles (GNPs… CONTINUE READING

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