Targeting cytokines to tumors to induce active antitumor immune responses by recombinant fusion proteins.

@article{Xiang1999TargetingCT,
  title={Targeting cytokines to tumors to induce active antitumor immune responses by recombinant fusion proteins.},
  author={Jim Xiang},
  journal={Human antibodies},
  year={1999},
  volume={9 1},
  pages={23-36}
}
Cytokines such as interleukin-2(IL-2), gamma interferon (IFN-gamma) and alpha tumor necrosis factor (TNF-alpha) are important mediators in immune responses against tumors. However, their therapeutic efficacy and clinical utilities in treatment of human malignancies are in large part limited due to the low concentrations of cytokine in tumors and the severe toxic side-effects derived from high-dose administration of cytokines. One critical issue to improve therapeutic efficacy is how to increase… CONTINUE READING

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