Targeting cystalysin, a virulence factor of treponema denticola-supported periodontitis.


Cystalysin from Treponema denticola is a pyridoxal 5'-phosphate dependent lyase that catalyzes the formation of pyruvate, ammonia, and sulfide from cysteine. It is a virulence factor in adult periodontitis because its reaction contributes to hemolysis, which sustains the pathogen. Therefore, it was proposed as a potential antimicrobial target. To identify… (More)
DOI: 10.1002/cmdc.201300527


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