Targeting constitutively-activated STAT3 in hypoxic ovarian cancer, using a novel STAT3 inhibitor

@inproceedings{McCann2014TargetingCS,
  title={Targeting constitutively-activated STAT3 in hypoxic ovarian cancer, using a novel STAT3 inhibitor},
  author={Georgia A. McCann and S Krishnamurthy Naidu and Kellie S. Rath and Hemant Kumar Bid and Brent J. Tierney and A. J. Alvarez-Morujo Su{\'a}rez and Saradhadevi Varadharaj and Jianying Zhang and K{\'a}lm{\'a}n Hideg and Peter James Houghton and Periannan Kuppusamy and David E. Cohn and Karuppaiyah Selvendiran},
  booktitle={Oncoscience},
  year={2014}
}
Tumor hypoxia, a feature of many solid tumors including ovarian cancer, is associated with resistance to therapies. We previously demonstrated that hypoxic exposure results in increased expression of phosphorylated signal transducer and activator of transcription 3 (pSTAT3). We hypothesized the activation of STAT3 could lead to chemotherapeutic resistance in ovarian cancer cells in hypoxic conditions. In this study, we demonstrate the level of pSTAT3 Tyr705 is increased in the hypoxic regions… CONTINUE READING

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