Targeting cell surface trafficking of pain-facilitating receptors to treat chronic pain conditions.

@article{Ma2014TargetingCS,
  title={Targeting cell surface trafficking of pain-facilitating receptors to treat chronic pain conditions.},
  author={Weiya Ma and R{\'e}mi Quirion},
  journal={Expert opinion on therapeutic targets},
  year={2014},
  volume={18 4},
  pages={459-72}
}
INTRODUCTION Chronic pain conditions are serious clinical concerns. Its genesis is closely associated with sensitization of nociceptive primary sensory neurons (nociceptors) and dorsal horn neurons by various pain mediators produced during inflammation and tissue injury. Growing evidence showed that increasing cell surface trafficking of pain-facilitating receptors is an important mechanism underlying the peripheral and central sensitization. AREAS COVERED We summarized the progress of this… CONTINUE READING
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