Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms.

@article{Wu2006TargetingCP,
  title={Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms.},
  author={Wenyuan Wu and Yunping Luo and Chengzao Sun and Yuan Liu and Paul Kuo and J{\'a}nos Tam{\'a}s Varga and Rong Xiang and Ralph A. Reisfeld and Kim D Janda and Thomas Scott Edgington and Cheng Liu},
  journal={Cancer research},
  year={2006},
  volume={66 2},
  pages={970-80}
}
The tumor microenvironment is notably enriched with a broad spectrum of proteases. The proteolytic specificities of peptide substrates provide modular chemical tools for the rational design of cell-impermeable prodrugs that are specifically activated by proteases extracellularly in the tumor microenvironment. Targeting cell-impermeable prodrug activation to tumor microenvironment will significantly reduce drug toxicity to normal tissues. The activated prodrug attacks both tumor and stroma cells… CONTINUE READING
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