Targeting cell death signaling in colorectal cancer: current strategies and future perspectives.

@article{Koehler2014TargetingCD,
  title={Targeting cell death signaling in colorectal cancer: current strategies and future perspectives.},
  author={Bruno Christian Koehler and Dirk Jaeger and Henning Schulze-Bergkamen},
  journal={World journal of gastroenterology},
  year={2014},
  volume={20 8},
  pages={1923-34}
}
The evasion from controlled cell death induction has been considered as one of the hallmarks of cancer cells. Defects in cell death signaling are a fundamental phenomenon in colorectal cancer. Nearly any non-invasive cancer treatment finally aims to induce cell death. However, apoptosis resistance is the major cause for insufficient therapeutic success and disease relapse in gastrointestinal oncology. Various compounds have been developed and evaluated with the aim to meet with this obstacle by… CONTINUE READING