Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

@article{Lock2013TargetingCA,
  title={Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche},
  author={Frances E. Lock and Paul C. McDonald and Yuanmei Lou and Isabel Serrano and Shawn C. Chafe and Christina Ostlund and S. Aparicio and J-Y Winum and Claudiu T. Supuran and Shoukat Dedhar},
  journal={Oncogene},
  year={2013},
  volume={32},
  pages={5210-5219}
}
The sub-population of tumor cells termed ‘cancer stem cells’ (CSCs) possess the capability to generate tumors, undergo epithelial–mesenchymal transition (EMT) and are implicated in metastasis, making treatments to specifically target CSCs an attractive therapeutic strategy. Tumor hypoxia plays a key role in regulating EMT and cancer stem cell function. Carbonic anhydrase IX (CAIX) is a hypoxia-inducible protein that regulates cellular pH to promote cancer cell survival and invasion in hypoxic… CONTINUE READING
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