Targeting cancer stem-like cells as an approach to defeating cellular heterogeneity in Ewing sarcoma.

Abstract

Plasticity in cancer stem-like cells (CSC) may provide a key basis for cancer heterogeneity and therapeutic response. In this study, we assessed the effect of combining a drug that abrogates CSC properties with standard-of-care therapy in a Ewing sarcoma family tumor (ESFT). Emergence of CSC in this setting has been shown to arise from a defect in TARBP2… (More)
DOI: 10.1158/0008-5472.CAN-14-1106

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@article{CornazBuros2014TargetingCS, title={Targeting cancer stem-like cells as an approach to defeating cellular heterogeneity in Ewing sarcoma.}, author={Sandrine Cornaz-Buros and Nicol{\`o} Riggi and C L Devito and Alexandre Sarre and Igor Letovanec and Paolo Provero and Ivan Stamenkovic}, journal={Cancer research}, year={2014}, volume={74 22}, pages={6610-22} }