Targeting cancer metabolism to develop human lactate dehydrogenase (hLDH)5 inhibitors.

Abstract

Cancer cells feature a switch in glucose metabolism from oxidative phosphorylation to cytoplasm-based glycolysis. This altered cellular metabolic pathway meets the survival and proliferation needs for tumor progression. Targeting the metabolic remodeling could offer opportunities for developing effective anticancer therapeutics. Human lactate dehydrogenase… (More)
DOI: 10.1016/j.drudis.2018.05.014