Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

  title={Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?},
  author={D. Trachootham and J. Alexandre and P. Huang},
  journal={Nature Reviews Drug Discovery},
  • D. Trachootham, J. Alexandre, P. Huang
  • Published 2009
  • Biology, Medicine
  • Nature Reviews Drug Discovery
  • Increased generation of reactive oxygen species (ROS) and an altered redox status have long been observed in cancer cells, and recent studies suggest that this biochemical property of cancer cells can be exploited for therapeutic benefits. Cancer cells in advanced stage tumours frequently exhibit multiple genetic alterations and high oxidative stress, suggesting that it might be possible to preferentially eliminate these cells by pharmacological ROS insults. However, the upregulation of… CONTINUE READING
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