Targeting calpain in synaptic plasticity.

  title={Targeting calpain in synaptic plasticity.},
  author={Michel Baudry and Maggie Meng-Hsiu Chou and Xiaoning Bi},
  journal={Expert opinion on therapeutic targets},
  volume={17 5},
INTRODUCTION Calpains represent a family of neutral, calcium-dependent proteases, which modify the function of their target proteins by partial truncation. These proteases have been implicated in numerous cell functions, including cell division, proliferation, migration, and death. In the CNS, where µ-calpain and m-calpain are the main calpain isoforms, their activation has been linked to synaptic plasticity as well as to neurodegeneration. This review will focus on the role of calpains in… CONTINUE READING
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