Targeting autophagy for drug-induced hepatotoxicity.

  title={Targeting autophagy for drug-induced hepatotoxicity.},
  author={Hong-Min Ni and Hartmut Jaeschke and Wenxing Ding},
  volume={8 4},
Autophagy is a lysosomal degradation pathway for bulk cytosolic proteins and damaged organelles, and is well known to act as a cell survival mechanism. Acetaminophen (APAP) overdose can cause liver injury in animals and humans by inducing necrosis due to mitochondrial damage. We recently found that pharmacological induction of autophagy by rapamycin protects against, whereas pharmacological suppression of autophagy by chloroquine exacerbates, APAP-induced liver injury in mice. Autophagy is… CONTINUE READING
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