Targeting apoptosis resistance in rhabdomyosarcoma.

  title={Targeting apoptosis resistance in rhabdomyosarcoma.},
  author={Simone Fulda},
  journal={Current cancer drug targets},
  volume={8 6},
Resistance of human cancers to current treatment approaches remains a challenge in oncology. Therefore, there has been much interest in identifying molecular pathways that are responsible for primary or acquired resistance of cancers. Since most anticancer therapies, i.e. chemotherapy or radiotherapy, primarily act by triggering programmed cell death (apoptosis) in cancer cells, defects in apoptosis programs may confer resistance. Evasion of apoptosis in rhabdomyosarcoma may be caused by the… CONTINUE READING