Targeting apoptosis pathways in pancreatic cancer.

  title={Targeting apoptosis pathways in pancreatic cancer.},
  author={Alexander Arlt and Susanne Sebens M{\"u}erk{\"o}ster and Heiner Sch{\"a}fer},
  journal={Cancer letters},
  volume={332 2},
Pancreatic cancer - here in particular pancreatic ductal adenocarcinoma (PDAC) - is still a highly therapy refractory disease. Amongst the mechanisms by which PDAC cells could escape any non-surgical therapy, anti-apoptotic protection seems to be the most relevant one. PDAC cells have acquired resistance to apoptotic stimuli such as death ligands (FasL, TRAIL) or anti-cancer drugs (gemcitabine) by a great number of molecular alterations either disrupting an apoptosis inducing signal or… CONTINUE READING
48 Citations
171 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 48 extracted citations


Publications referenced by this paper.
Showing 1-10 of 171 references


  • S. Banerjee, Z. Wang
  • Kong, F.H. Sarkar, 3,30-Diindolylmethane…
  • 2009
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…