Targeting antioxidants to mitochondria: a potential new therapeutic strategy for cardiovascular diseases.

@article{Victor2007TargetingAT,
  title={Targeting antioxidants to mitochondria: a potential new therapeutic strategy for cardiovascular diseases.},
  author={Victor M Victor and Milagros Rocha},
  journal={Current pharmaceutical design},
  year={2007},
  volume={13 8},
  pages={
          845-63
        }
}
Mitochondria produce large amounts of free radicals and play an important role in the life and death of a cell. Thus, mitochondrial oxidative damage and dysfunction contribute to a number of cell pathologies that manifest themselves through a range of conditions including ischemia-reperfusion injury, sepsis, diabetes, atherosclerosis and, consequently, cardiovascular diseases (CVD). In fact, endothelial dysfunction, characterized by a loss of nitric oxide (NO) bioactivity, occurs early on in… CONTINUE READING

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