Targeting antigen to bone marrow stromal cell-2 expressed by conventional and plasmacytoid dendritic cells elicits efficient antigen presentation.

@article{Moffat2013TargetingAT,
  title={Targeting antigen to bone marrow stromal cell-2 expressed by conventional and plasmacytoid dendritic cells elicits efficient antigen presentation.},
  author={Jessica M. Moffat and Elodie Segura and Gabriela Khoury and Irene Caminschi and Paul U Cameron and Sharon R. Lewin and Jose A Villadangos and Justine D Mintern},
  journal={European journal of immunology},
  year={2013},
  volume={43 3},
  pages={
          595-605
        }
}
Bone marrow stromal cell-2 (BST-2) has major roles in viral tethering and modulation of interferon production. Here we investigate BST-2 as a receptor for the delivery of antigen to dendritic cells (DCs). We show that BST-2 is expressed by a panel of mouse and human DC subsets, particularly under inflammatory conditions. The outcome of delivering antigen to BST-2 expressed by steady state and activated plasmacytoid DC (pDC) or conventional CD8(+) and CD8(-) DCs was determined. T-cell responses… CONTINUE READING
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Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivo.

Proceedings of the National Academy of Sciences of the United States of America • 2011