Targeting angiogenic metabolism in disease Targeting endothelial cell metabolism offers new therapeutic opportunities for various conditions

@inproceedings{Carmeliet2018TargetingAM,
  title={Targeting angiogenic metabolism in disease Targeting endothelial cell metabolism offers new therapeutic opportunities for various conditions},
  author={Peter Carmeliet},
  year={2018}
}
B lood vessels, which are lined by endothelial cells (ECs), supply oxygen and nutrients to every cell in the body. When tissues (or tumors) grow, they stimulate ECs to form new blood vessels (angiogenesis), so that they become better nourished. Hence, inhibiting angiogenesis to starve tumors has become a clinically approved therapy. For more than 40 years, antiangiogenic medicine has focused on targeting angiogenic signaling proteins, such as vascular endothelial growth f actor (VEGF). However… CONTINUE READING