Targeting androgen receptor to suppress macrophage-induced EMT and benign prostatic hyperplasia (BPH) development.

@article{Lu2012TargetingAR,
  title={Targeting androgen receptor to suppress macrophage-induced EMT and benign prostatic hyperplasia (BPH) development.},
  author={Tianjing Lu and Wen-Jye Lin and Kouji Izumi and Xiaohai Wang and Defeng Xu and Lei-Ya Fang and Lei Li and Qi Chuan Jiang and Jie Jin and Chawnshang Chang},
  journal={Molecular endocrinology},
  year={2012},
  volume={26 10},
  pages={
          1707-15
        }
}
Early studies suggested macrophages might play roles in inflammation-associated benign prostatic hyperplasia (BPH) development, yet the underlying mechanisms remain unclear. Here we first showed that CD68(+) macrophages were identified in both epithelium and the stromal area of human BPH tissues. We then established an in vitro co-culture model with prostate epithelial and macrophage cell lines to study the potential impacts of infiltrating macrophages in the BPH development and found that co… CONTINUE READING

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