Targeting and gene expression in spinal cord motor neurons following intramuscular inoculation of an HSV-1 vector.

@article{Keir1995TargetingAG,
  title={Targeting and gene expression in spinal cord motor neurons following intramuscular inoculation of an HSV-1 vector.},
  author={Stuart D. Keir and Willam J. Mitchell and Lawrence T. Feldman and John R Martin},
  journal={Journal of neurovirology},
  year={1995},
  volume={1 3-4},
  pages={259-67}
}
One problem in devising strategies of gene transfer to the nervous system is targeting specific neuronal populations. To evaluate the potential for using herpes simplex virus (HSV) as a vector for gene transfer to spinal cord motor neurons, the HSV-1 mutant LAT-LTR in which the E. coli beta-galactosidase gene is expressed under control of the HSV LAT core promoter (LAT) and the Moloney murine leukemia virus long terminal repeat (LTR) was inoculated unilaterally into the gastrocnemius muscle… CONTINUE READING

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