Targeting an Oncolytic Influenza A Virus to Tumor Tissue by Elastase

Abstract

Oncolytic viruses are currently established as a novel type of immunotherapy. The challenge is to safely target oncolytic viruses to tumors. Previously, we have generated influenza A viruses (IAVs) containing deletions in the viral interferon antagonist. Those deletions have attenuated the virus in normal tissue but allowed replication in tumor cells. IAV… (More)
DOI: 10.1016/j.omto.2017.09.002

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