Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.

@article{Lee2006TargetingAP,
  title={Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.},
  author={Edward K. B. Lee and Lewis Z. Leng and Bin Zhang and Linda W Kwong and John Q. Trojanowski and Ted Abel and Virginia M-Y Lee},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 7},
  pages={4292-9}
}
Passive immunization of murine models of Alzheimer disease amyloidosis reduces amyloid-beta peptide (Abeta) levels and improves cognitive function. To specifically address the role of Abeta oligomers in learning and memory, we generated a novel monoclonal antibody, NAB61, that preferentially recognizes a conformational epitope present in dimeric, small oligomeric, and higher order Abeta structures but not full-length amyloid-beta precursor protein or C-terminal amyloid-beta precursor protein… CONTINUE READING
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